helixstreet.io is a Polkadot SDK chain and autonomous Google Cloud agent fleet that records what genomic and proteomic datasets exist, who owns them, who granted access, and what was computed against them — without putting the underlying sequences on chain.
Track: The Fortified Enterprise Fleet. Competing in one of the largest AI agent hackathons globally ($180,000 USD in prizes across 12,260 participants evaluated by 78 Google & GDE judges), helixstreet won Best Architectural Design. Drop a raw sequencing file (BAM) into a Cloud Storage bucket and walk away — no chat loop, no clicks, no waiting human. Eventarc wakes a governed five-agent fleet on Google ADK: a Gemma 4 31B intake gatekeeper screens with Model Armor and scrubs PII via Cloud DLP, Gemini 3.5 Flash dispatches Google DeepVariant on Cloud Batch, goes dormant across the compute gap, wakes itself when the VCF lands, cross-references 1000 Genomes in BigQuery and CPIC pharmacogenomics, and seals a tamper-evident digital twin in ~9 minutes.
helixstreet_intake (Gemma 4 31B) + 4 Gemini 3.5 Flash specialists with live OpenTelemetry / Cloud Trace spans.
CYP2C19 *2/*2 clopidogrel alert with Europe PMC citations.
COMMITMENT_ANCHORED) + SHA-256 audit chain verified on every refresh.
Nemotron-3 Nano 30B / Super 120B) and NVIDIA Clara Parabricks for multi-cloud sovereign deployments.
Our long-horizon mission is to advance all forms of life and health, enhance human biology, and cryptographically preserve the genomic blueprints of Earth's species as humanity expands toward Mars. By sealing genomes in salted Merkle trees and SHA-256 ledgers, altering a single base pair changes the root hash — giving us mathematical, tamper-evident proof of authentic, original life. NO LIMITS AT THE FRONTIER OF AI, GENOMICS & PROTEOMICS.
We are measured by systems in production: winner of Best Architectural Design in Google's All Things Agentic Hackathon ($180,000 prize pool · 12,260 participants · 78 judges), Polkadot validators consistently graded A+ with top-tier slot inclusion and era performance, and public RPC nodes delivering 100.00% availability at the lowest latencies on the network. WE DELIVER REAL RESULTS — NOT LINKEDIN AND TWITTER NOISE. WE DELIVER.
A focused, senior engineering core amplified by a governed fleet of autonomous AI agents — orchestrated during the Google hackathon and in daily engineering with our own multi-agent orchestrator uta (unleashtheagents.ai) ↗. No bloated committees, no performative roadmaps, and zero organizational drag — WE DO NOT OVERTHINK. WE JUST DO.
Salted Merkle trees and hash-chained ledgers seal human and planetary genomes against silent mutation or tampering. Modify a single nucleotide and the cryptographic root changes — establishing mathematical proof of original biological life on Earth and for future habitats on Mars.
ZK circuits in the style of Icefish (IACR 2026/463) let you prove "my genotype meets the inclusion criteria" without revealing the genotype.
Connections validated by both data providers and approved through transparent on-chain governance.
Decentralized groups making drug development and safety rating more objective through collective intelligence.
Application-specific blockchain built for life sciences, supporting genomic and proteomic datasets natively.
Secured by Polkadot's shared validator set via coretime, with XCM v5 to compose with KILT identity, Crust storage and the wider ecosystem.
Ancestry data and links in the helixstreet parathread can be utilized by other chains to create Clans in the Metaverse. Through Cross Consensus Messaging (XCM), Metaverse projects can integrate real-life data and relationships.
The helixstreet foundation is a Swiss foundation stewarding the protocol, its open standards, and its validators.
The Future is Multi-Chain →A Polkadot validator, Asset Hub and People Chain collators, and public JSON-RPC endpoints for all of them, operated by the helixstreet team. No hidden infra, no third-party rentals.
Each strand is a chain, each bead a block, right edge is now: horizontal distance is seconds. Bead size follows the block's extrinsic count, hollow beads await finality, filled beads are final. Blocks authored by helixstreet.foundation/2 glow white once our collator is in the active set.
1HMQVknF2rGz2vBegqA9jU4NhZKQtW7nZTDQykgeSm8FgPa
Polkadot's nominate flow does not accept a deep-link target — copy the stash above, then paste it into the dashboard's Favorites. Grade and performance numbers from turboflakes ONE-T.
wss://rpc-polkadot.helixstreet.io
wss://rpc-kusama.helixstreet.io
wss://rpc-asset-hub-polkadot.helixstreet.io
wss://rpc-people-polkadot.helixstreet.io
# chain name over HTTPS — one-liner sanity check curl -H "Content-Type: application/json" \ -d '{"id":1,"jsonrpc":"2.0","method":"system_chain","params":[]}' \ https://rpc-polkadot.helixstreet.io
Post inclusion criteria as a circuit. Participants submit an eligibility proof generated locally against their VCF. You learn who qualifies, not what their genome looks like.
Every access request, grant, and revocation is a signed extrinsic. If your data is used in a study, the consent receipt sits next to the result — you can revoke prospectively at any time.
Sequence-alignment proofs and verifiable GWAS pipelines anchor "this result was computed against this consented cohort with this method" to the chain. Useful for regulators, partners, and downstream IP NFTs.
helixstreet doesn't reinvent identity, storage, or biotech-IP rails. It speaks XCM v5 to chains that already do those things well.
Listed peers are independent projects we compose with technically; this is not a statement of formal partnership.
Beyond the chain itself, helixstreet advises large pharmaceutical companies on where blockchain actually helps a life-sciences workflow — and, just as often, where it doesn't.
Consent and access audit trails, provenance of derived datasets, multi-party trial coordination, IP-NFT settlement, supply-chain attestations for biologics. Each one is a problem regulators already understand.
Putting raw genomes on chain. "Tokenize the patient." Anonymous DNA marketplaces. AI-on-genomes-on-chain combo plates. We will tell you no, in writing, with the references.
Scoped reviews, architecture workshops, and reference implementations on testnet. We work in writing, with citations, and against a defined exit criterion. Get in touch →
helixstreet is Polkadot-native by design, but life sciences is a 20-year problem and the substrate matters less than the guarantees. These are the platforms we keep instrumented and benchmark against.
We benchmark consent-flow and proof-verification primitives against each of these on a rolling basis. When something there beats Polkadot for a specific life-science workload, we say so — and the advisory engagements above reflect that.
helixstreet.foundation/2 at A+ grade, Asset Hub and People Chain collators (metanode phase 1, dedicated metanode build in preparation), public RPC endpoints for Polkadot, Kusama, Asset Hub and the People Chains. Testnet: consent-receipt pallet, ZK eligibility-proof verifier. Roadmap: mainnet launch on Polkadot coretime, XCM bridges to KILT/Crust, federated-kinship coordinator. See the roadmap.helixstreet.foundation validators earns standard Polkadot staking rewards at 0% commission and creates no claim on helixstreet. Nominate because the nodes run well. Nominate our validators →
How we built an event-driven, zero-chat-loop autonomous genomic fleet on Google ADK, Gemini 3.5 Flash, Gemma 4, and DeepVariant — and the five production bugs that shaped it.
Updated for Polkadot 2.0. What's actually involved in stitching consent, identity, storage and IP-settlement across chains via XCM v5 — with a concrete pseudo-XCM example.
Twins, theft, family leakage, irrevocability. The honest case against using genomes as a Sybil-resistance primitive, with the credible alternatives in zk-eligibility and HE-coordinated kinship.